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Numeric efficacy endpoints were tested using separate linear models to compare (1) L-Carnitine to placebo and (2) L-Carnitine-combination to placebo

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In the endosome, Fe 3+ is reduced to Fe 2+ , and the latter is transported out by the divalent metal ion transporter 1 (DMT1) or the zinc-iron-regulatory protein family 8/14 (ZIP8/14) ( 2+ is involved in the unstable iron pool (LIP)