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Individuals with a BMI of 30 kg/m or higher may qualify directly, while those with a BMI of 27 kg/m or higher may be eligible if they have weight-related health conditions like hypertension, type 2 diabetes , elevated cholesterol, or obstructive sleep apnea

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Because eccDNA detection is method-sensitive with different enrichment strategies and computational pipelines recovering only partially overlapping eccDNA sets and producing method-dependent size spectra and genomic annotations ( Interestingly, genes that frequently appear on eccDNA also tend to be highly expressed (Mller et al., 2015b