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performed the literature search
16 GLP-1RAs achieve sustained pharmacological effects by resisting degradation by DPP-4 in the body, consequently contributing to hyperglycemia and insulin resistance related to glucose metabolism, 17,18 lipid profile alterations, changes in fat composition, visceral fat accumulation, and obesity related to lipid metabolism, 1921 which constitute the systemic metabolic characteristics of interest in MASLD management
However, analyses of single-agent interventions found that neither exenatide nor liraglutide significantly affected the risk of DKA in individuals with T1DM, indicating insufficient evidence to support a definitive protective or harmful effect at the individual drug level
Every patients metabolism differs, which is why losing weight can be a difficult process in the first place
Frontiers in reproductive health, 8, 1745210
