Tirzepatide Research# SURPASS program (Type 2 diabetes): Five Phase 3 trials demonstrating superior HbA1c reduction compared to insulin glargine, semaglutide, and insulin degludec SURMOUNT program (Obesity): Phase 3 trials showing up to 20.9% weight loss at 72 weeks FDA approvals : Mounjaro (May 2022) for T2D
May take longer based on weather, holiday, or lab delays
The lack of traditional Part D controls and unclear prescriber oversight could increase risk of overprescribing and potential fraud
Traditionally GLP-1(9-36) was considered inactive, however more recent studies indicate that GLP-1(9-36) can contribute to inhibiting glucagon secretion by inhibiting voltage-gated calcium channels through a GPCR mechanism, an effect which reduces the number of glucagon containing vesicles that are available for exocytosis, thereby contributing the the decrease in glucagon secretion (Figure 1)(Zheng et al, 2024)
both meet GMP and third-party testing standards with verified ingredient sourcing