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K + balance and water homeostasis are maintained through Kir4.1 and AQP4 channels, respectively, which are localized at the perivascular endfeet 108,109

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Overall, these findings indicate that reductions in GPx3 abundance trends with disease severity with stage 1 having the highest mean levels of GPx3 (1.99 g/ml 0.73 g/ml) and the highest K1/U1 ratio (0.86), followed by the stage 2 with a mean of 1.2 g/ml 0.54 g/ml and average K2/U2 ratio of 0.67, with the most severe form of konzo, stage 3, displaying the largest reduction in average protein abundance (mean: 1.15 g/ml 0.58 g/ml) and the lowest K3/U3 ratio of 0.59 (Supplementary Data 1)

Yes, when monitored clinically, IGF-1 LR3 shows predictable receptor activity and a well-tolerated safety profile in preclinical human data, provided glucose and hormone levels are regularly evaluated

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