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This sensitization to TGF-beta signaling augments expression of matrix genes including collagens, fibronectin, and proteoglycans, while appropriate regulation prevents excessive TGF-beta activity associated with pathological fibrosis

Western blot analysis The Western blot assay was performed as previously described 24,88

Side effects are rare and usually mild, such as slight discomfort at the injection site

2 Methods A comprehensive literature search was conducted to identify studies relevant to mitochondrial reactive oxygen species (mtROS), skeletal muscle atrophy, and supraspinatus degeneration following rotator cuff injury