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Aib mimics the structure of d-amino acids, which considerably increases resistance against protease enzymes such as DPP-IV, leading to an extended half-life of up to 5 days
When you escalate, those adaptations are suddenly inadequate for the new pharmacologic effect
Accordingly, the functional impact of NAD metabolism is determined not only by absolute pool size but also by turnover flux, compartmental exchange, and redox coupling across tissues
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