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Li J, Lian T, Li J et al (2025b) Alzheimers disease with depression: clinical characteristics and potential mechanisms involving orexin and brain atrophy
For confirmed deficiency with neurological symptoms , intramuscular cyanocobalamin injections are preferred, typically administered as 1000 mcg daily for one week, then weekly for four weeks, followed by monthly maintenance therapy
however, many of these studies have small sample sizes, typically involving fewer than 50 participants (Nie et al., 2023)
Data showed that participants using semaglutide alongside lifestyle changes achieved a mean weight reduction of approximately 14.9% [3] , compared to just 2.4% in the placebo group over 68 weeks
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