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Under normal conditions, about 12% of total consumed oxygen is converted to superoxide radical anion and hydrogen peroxide, however, under hyperglycemic conditions, the conversion of oxygen to superoxide radical increases up to 10%
Mod Pathol
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Pharmacometabolomics is a valuable method for examining the alterations in metabolites resulting from disorders or environmental factors and predicting the efficiency or potential toxicity of a specific drug intervention (Corona et al., 2012)
Methods Ethical approval All animal experiments reported herein were performed following the guidelines and were approved by Peking University Institutional Animal Care and Use Committee (LA2021316)
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