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This fundamental principle is called progressive overload
Chin YH, Ng CH, Chew NW, Kong G, Lim WH, Tan DJH, et al
The drug had a half-life of about one week and stronger effects on glycaemia and body weight with mean reductions in HbA 1c of 18 mmol/mol and in body weight of 5.7 kg in the phase-III programme [20]
Shiff SJ, Koutsos MI, Qiao L, Rigas B (1996) Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis
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