oral semaglutide versus subcutaneous semaglutide Dose-equivalence reference based on pivotal GLP-1/dual-agonist trials: SURMOUNT-1 (tirzepatide/Zepbound, 72 weeks) STEP-1 (subcutaneous semaglutide/Wegovy, 68 weeks) OASIS-4 (oral semaglutide/Wegovy, 64 weeks). For educational comparison only—these are Comparative Effectiveness and Safety of

341 Disrupting TAM and MDSC recruitment and reprogramming their polarization is another effective strategy

The confidentiality of the collected data was strictly maintained for the purposes of this study

A typical semaglutide titration: Weeks 1-4: 0.25mg once weekly Weeks 5-8: 0.5mg once weekly Weeks 9-12: 1.0mg once weekly Weeks 13-16: 1.7mg once weekly Week 17 onward: 2.4mg once weekly (maximum maintenance dose) A typical tirzepatide titration: Weeks 1-4: 2.5mg once weekly Weeks 5-8: 5.0mg once weekly Weeks 9-12: 7.5mg once weekly Weeks 13-16: 10mg once weekly Week 17 onward: 12.5-15mg once weekly (if needed) Some researchers find their optimal dose well below the maximum

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It also supports skin repair and regeneration, leaving it looking smoother and more supple