Curr Opin Neurobiol 81:102733 Hasegawa E, Miyasaka A, Sakurai K et al (2022) Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice
In contrast, its use in specific clinical contextssuch as circadian rhythm sleep disorders, neurodegenerative diseases, or metabolic dysregulationis addressed as an adjunctive therapeutic approach, where evidence remains heterogeneous and often limited to small-scale or short-term studies
When results show, and how long they last: Many feel a lift within 2472 hours, while others notice gradual improvement over one to two weeks
For patients who are not candidates for GLP-1-RAs and have a contraindication to topiramate (e.g., nephrolithiasis) and/or phentermine (e.g., uncontrolled hypertension), monotherapy bupropion or bupropion/naltrexone might be considered, though little data exists regarding its efficacy after bariatric surgery
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