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Ago-PAMs, acting as agonists on their own and as enhancers for orthosteric ligands, are capable of increasing agonist potency and providing additional efficacy 44 , thereby offering an alternative to conventional therapeutics

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Congress and the FDA also placed limits on which bulk active ingredients can be used

Genes Dev 29:14161431 Smith DB, Johnson KS (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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