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These include individuals with a personal or family history of medullary thyroid carcinoma, those diagnosed with multiple endocrine neoplasia syndrome type 2, patients with severe gastrointestinal conditions such as gastroparesis, individuals who are pregnant or breastfeeding, and patients with severe renal impairment

Administered via subcutaneous injection at typical doses of 200-300 mcg daily, ipamorelin has a short half-life of approximately two hours but produces both immediate and sustained growth hormone pulses without elevating cortisol levels

10.1371/journal.pone.0046718 PLOS ONE 14 DietrichL

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