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It is important to note that when fat cells grow larger, they release nicotinamide N-methyltransferase (NNMT), which slows down metabolism and further leads to weight gain
In contrast, another study in rats demonstrated that acute injection of the GLP-1R agonist exendin-4 (Ex-4) increases baseline glucose levels in rats which is due to the activation of the sympathetic nervous system (Perez-Tilve et al., 2010)
One important debate concerns the mechanisms underlying GLP-1RA benefits in non-metabolic diseases
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