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Aiding Weight Loss If you have PCOS, you may find it harder to lose weight, and much of this is linked to insulin resistance

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And in short that came out a few years after that STEP 1 trial what we did for the very first time is take individuals with obesity and pre-existing cardiovascular disease, like a prior stroke, prior heart attack, or peripheral arterial disease, called PAD, and they're on maximal therapy for their cardiovascular disease or stroke, and then randomized them on top of that to either semaglutide or placebo

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The clinical trials included plenty of participants without diabetes who just needed to lose significant weight