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Patients ( N = 148) with type 2 diabetes with inadequate glycemic control on metformin (median duration of disease of 6.7 years, mean baseline HbA 1c 5557 mmol/mol [7.27.4%]) were randomised to receive lixisenatide (initiated at 10 g OD for 2 weeks followed by 20 g OD), or liraglutide (started at 0.6 mg and titrated up to 1.8 mg OD)

Cellular Adaptation and hyperplasia Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation

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When the adrenal system is under sustained strain, these other systems may begin to reflect that imbalance

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