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GLP-1 Receptor Activation and Cardiovascular Tissue Expression The distribution of GLP-1 receptors (GLP-1R) throughout cardiovascular tissues provides the anatomical foundation for the cardioprotective effects of GLP-1 receptor agonists
However, various observational studies have shown that metformin may even lead to a reduction in mortality in patients with heart failure [60], so according to current understanding, metformin can be considered a safe drug for patients with diabetes and heart failure
The estimates above are based on trial completion dates and standard regulatory timelines
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