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Compared with the wild type, GhGPX4 -overexpressed Arabidopsis exhibited reduced staining at pollen developmental stages 6, 7, and 911, indicating a lower accumulation of O 2 - in the pollen

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This assertion was further verified by a series of intervention studies, where improvement of lipid solubility and intestinal permeability as well as inhibition of intestinal flora increased the relative bioavailability to different extents without being changed by P-gp inhibition

arXiv preprint arXiv:1208.5347.