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Of these 32 semaglutide-treated patients that developed anti-semaglutide antibodies, 19 patients (0.6% of the overall population) developed antibodies cross-reacting with native GLP-1

Involved in cellular signaling and regulating calcium levels, CD38 degrades NAD + , using it as a co-substrate for its enzymatic activity 135,136

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Therefore, maintaining a balanced diet rich in fiber and probiotics can be beneficial for patients on GLP-1 therapy, helping to mitigate some of the gastrointestinal side effects

Stamler et al, 1993)