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This is not a soft recommendation
When the pulmonary arterial hypertension indication was pursued and approved (as Revatio), it generated additional exclusivity, though the commercial significance was modest relative to the primary erectile dysfunction market
Current chronic daily treatment with an orally administered steroid at a dose equivalent to 10 mg of orally administered prednisolone
RECLAIM ran three times as long and the endpoint moved anyway, with a blood test pointing the same way as what people said about their own drinking
However, these preservatives also have a shelf life
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