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Because its a fragment of the full hormone, it tends to have a more targeted effect with fewer systemic side effects

Some researchers have also raised questions about the potential for developing tolerance or dependence with long-term use, although current evidence does not suggest a high risk of addiction

This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway