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It selectively activates melanocortin-1 receptors (MC1R), influencing melanin production in melanocytes

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Association of body weight reduction and changes in HOMA2-IR The relationship between body weight reduction and changes in HOMA2 parameters was assessed among the subgroups of participants with study-defined prediabetes treated with tirzepatide or semaglutide

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That receptor spread is the reason people sometimes describe retatrutide as a "triple agonist" or, informally, a next-generation GLP-class compound

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