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These enzymes are responsible for the metabolism of both exogenous and endogenous compounds
Plasma levels of GHK have been documented to decline from approximately 200 ng/mL at age 20 to roughly 80 ng/mL at age 60, a 60% drop [1]
The estimated treatment difference is therefore 20.4 points under the trial product estimand and 17.3 under treatment policy: a gap of roughly 3.1 points on the effect estimate, not 2.3
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