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Journal of Molecular Neuroscience, 72(6), 13001312
The limitations of the study, as acknowledged by the authors, include the lack of individual patient data and the relatively low percentage of participants with a history of stroke
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In animal experiments, the GLP-1RA liraglutide was found to stimulate the secretion of ANP by increasing the levels of Epac2, which is a downstream target of GLP-1R signaling in cardiomyocytes (132), However, this finding seemed to contradict the results of clinical studies in which no increase was observed in the levels of ANP in healthy people and patients with T2MD
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