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conducted clinical research and reported that MSU not only stimulates white blood cells to produce more LTB4 but also inhibits LTB4 metabolism, causing it to persist and recruit more neutrophils ( The subsequently released LTB4 causes neutrophils to adhere to and become trapped within the blood vessels, leading to their extravasation and migration from the bloodstream into the inflamed tissue

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With greater nitric oxide production, the blood vessels widen in an effect known as vasodilation , leading to improved blood flow and muscle pumps

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