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Whilst some probiotic strains may theoretically influence endogenous GLP-1 secretion through metabolite production, there is no established evidence that supplements achieve clinically meaningful increases in circulating GLP-1 levels
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Time to first MACE (semaglutide vs comparators) across the continuum of baseline CV risk For the main endpoint (time to first MACE), and for each individual component of MACE, the combined semaglutide trial data were analyzed for up to 2 years (to align with the observation time used as the basis for the risk prediction model) using a Cox proportional hazards model stratified according to a 4-group categorization by trial program (SUSTAIN or PIONEER) and trial type (CVOT or glycemic efficacy trial)
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