For example, in the EMPA-REG OUTCOME trial, patients randomized to receive empagliflozin experienced a significant reduction in cardiovascular death, all-cause mortality, and hospitalization for heart failure compared to placebo despite only modest differences in HbA1c between groups [22]
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Funding This study was supported by Natural Science Foundation of Guangdong Province (2021A1515012393), NSFC grant (82371692, 32170825), Key laboratory of functional and clinical translational medicine, Guangdong Provincial Sports Bureau Scientific Research Project (GDSS2024N007), and Guangdong Medical Science and Technology Research Foundation (A2023145)