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Reducing the recruitment of -arrestin and the residence time of the ligand towards the receptor, thus decreasing internalization, is presumably the key of incretin drugs
But step therapy can potentially harm a patient and make treatment longer and more expensive if an insurer first requires a treatment not recommended by the patients physician
So I did the calculation on this to hit the LD 50 of cyanide from Sano cabal, which by the way, you still wouldn't be toxic because cyanide is only dangerous
Side effects that remain intolerable despite adaptation time may indicate the need for dose reduction
While hydration and electrolytes are important during GLP-1 treatment, your long-term success depends heavily on digestive healthespecially when transitioning off these medications
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