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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist available in the US under two brand names: Mounjaro (for type 2 diabetes in adults) and Zepbound (for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity)
We utilized an in vivo hemocyte reporter system ( msn-mCherry and eater-GFP
At the end of the experiment, it is sacrification was performed by decapitation
Transitioning off GLP-1s requires ongoing support, with specialized care between doctors visits to support healthy behaviors and weight maintenance
The results of both positive and negative outcome analyses further strengthen our approach and underscore the potential benefits of GLP-1 RAs in different follow-up strategies across subgroup analysis and sensitivity tests
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