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Foundational work from the de Keizer laboratory (Baar et al., Cell, 2017) reported that the peptide perturbs the FOXO4-p53 association, leading to p53 nuclear exclusion and apoptosis that appeared preferential to senescent cells in cultured cells and aged mouse models
I have also run several simpler gradients ranging from 1/99 to 99/1 with and without formic acid with no real luck
Both act through separate receptor pathways and together produce a synergistic, supra-additive GH pulse
& Harper, M
doi:10.1002/hup.2767
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