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PMID 17414839

In the tubules, GLP1 induces a natriuretic effect, decreasing the activity and expression of sodium-glucose cotransporters type I and II (SGLT1/2) as well as reducing the activity of the NH3 exchanger through phosphorylation, leading to increased Na+ presence in the macula densa, restoring tubuloglomerular feedback with afferent vasoconstriction and reduction of intraglomerular pressures

When designing combination protocols, researchers should account for possible interactions, adjust doses, use enhanced safety monitoring, and include appropriate controls