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Lower volumes create higher concentrations, requiring smaller injection volumes
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In contrast to the Kataoka's mice model where PLC was expressed in a shortened and catalytically inactive form, the knockout models described by Martins and coauthors either have a complete loss of the PLC expression (PLC -/- ) or have expression of the mutant form of PLC with mutant RA domains enable to bind to Ras (PLC RAm/RAm )
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