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Recent clinical data suggests they are well-tolerated , but they should only be used under medical supervision
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Selected candidates were women who were diagnosed with uterine leiomyoma based on transvaginal ultrasounds, and had a fibroid at least 8 cm or more, less than 4 uterine fibroids and just one type of fibroid (either submucosal, intramural or subserosal), with no pedunculated fibroids, were premenopausal, not pregnant, had not taken hormonal medications in the previous 6 months and no hormonal medication for their fibroids in the past 3 months and did not have certain diseases that were listed as exclusionary criteria
Additionally, deficiencies of HDAC1 and HDAC2 can reduce cell survival via decreasing the acetylation status of H3K56ac, H4K16ac and H4K91 [68], suggesting the positive effects of HDAC1 and HDAC2 on cell survival
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