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In a 68-week clinical trial, participants receiving semaglutide experienced an average body-weight reduction of 14.9% from baseline

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Still, treatment with LA improves aspartate transaminase, serum gamma glutamyl transpeptidase, and histological scores of the liver to a certain degree

Consequently, exogenous drugs that act on GLP-1Rs increase insulin sensitivity, possibly because GLP-1R stimulation compensates for some of the impaired insulin signaling

Lane 16: trypsin digestion of 6mGLP-1 for 15, 30, 45, 60, 90, 120 min at 37C, respectively