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Semaglutide is prescribed with a titration schedule starting at 0.25mg and increasing monthly

Just based on two high level metrics when it was removed from the shortage list (based on pharmacy supply calls and patients pick up rates here at Ro): Pharmacy Supply Calls: 38% of pharmacies have stock 15% do not have stock but expect to have it in the future 48% say its on back order and materially less supply than other Wegovy doses Patient pick up rates: 30-35% are able to find supply in 14 days 65-70% are able to find supply in 30 days If providers are using the FDAs list to determine what path to recommend for their patients, we need to ensure the FDA has as much information as possible to make that determination

Match the semaglutide name to the medicine your healthcare professional intended

Patients taking Semaglutide report intermittent nausea, but mostly in the beginning few weeks

## The Four Major GLP-1 Medications at a Glance A 2024 network meta-analysis in *The Lancet Diabetes & Endocrinology* compared GLP-1 receptor agonists across 28 randomized controlled trials