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TAMs, predominantly of the M2-like phenotype, and MDSCs secrete immunosuppressive cytokines (e.g., IL-10, TGF-) that inhibit T cell function and drive immune exhaustion
When exposed to A or other stressors, reactive astrocytes demonstrate increased glucose uptake and glycolysis, leading to enhanced ATP and lactate production 77
Panels D, E, and F show the corresponding concentration curves for GSH
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