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Activation of mTOR and upregulation of HIF-1 trigger enhanced glycolytic reprogramming in innate immune cells, which fulfills the elevated metabolic demands of trained immunity and synergizes with epigenetic remodeling to sustain the long-term pro-inflammatory and anti-pathogen memory phenotype of innate cells ( C

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Top image credit: Cixia Bottom image credit: Tim Kubacki Drug rash Matibot / Wikimedia Commons What it looks like : Drug rashes are usually speckled, itchy, and red, and can cover large areas of skin