why does tirzepatide make me so tired You Sleepy? Fatigue Explained If you’re on a GLP-1

The patient who changed how I think about this A 47-year-old woman with Hashimotos thyroiditis

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Instead, GLP-1 promotes the polarization of Th2 and regulatory T (Treg) cells, increasing anti-inflammatory cytokines such as IL-10 and IL-5 (55, 56)

Chinese Journal of Practical Internal Medicine

The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16