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Robert, 1979
Biomed Pharmacother 2016 Citrus aurantium flowers essential oil protects liver against ischemia/reperfusion injury
As a result, the gut becomes a central organ of dysfunction, capable of perpetuating systemic inflammation, modulating neurodevelopment through the gutbrain axis, and even altering endocrine rhythms via microbial metabolites and immune signaling 73,74
Subsequent research papers yielded conflicting results (Table 1), but starting from the meta-analysis conducted in 2009 by Medica and coworkers in 623 MDS and 936 control mothers (Medica et al., 2009), all the following meta-analyses confirmed association of this polymorphism with maternal risk for trisomy 21 in the offspring, with overall ORs ranging from 1.2 to 1.6 depending on the genetic model under investigation (Table 2)
One such treatment that we may consider is Glutamine IV therapy
