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The spore-forming single strain Clostridium butyricum (CBM588) improved progression-free survival and yielded higher response rates when added to nivolumab/ipilimumab in a randomized phase I study of metastatic renal cell carcinoma, and showed a further clinical activity signal when combined with nivolumab plus cabozantinib as first-line therapy, supporting a plausible immunomodulatory contribution of microbiome tuning to ICI outcomes [267, 268]
Vasilopoulos Y, Sagoo GS, Cork MJ, Walters K, Tazi-Ahnini R
10,11,13,24,26,29,3032,34 Therefore, this section outlines evidence for a biological mechanism through which GLP-1 can enhance healthspan and reduce the effects of aging
[16] Patients should contact their GP promptly if they experience persistent vomiting, signs of dehydration, severe abdominal pain, or any concerning symptoms