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Several reports now highlight small molecules that potentiate the action of the active peptide GLP- 1 (7-36)
SURPASS-4, a multicenter open-label RCT comparing treatment with tirzepatide and insulin glargine in T2D patients at increased CV risk for a median of 85 weeks, was the only study in the SURPASS program to include the change from baseline in eGFR and UACR and occurrence of eGFR decline of at least 40%, renal death, progression to end-stage kidney disease or new-onset MA among the prespecified analyses [48]
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While semaglutide itself has not been linked to increased clotting risk, patients prescribed this medication often have underlying conditions like obesity and diabetes that independently increase thrombotic risk
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