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In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more
At the time of writing, the FDA has so far noted an absence of safety concerns based on their review to date and is considering exercising enforcement discretion regarding the sale and distribution of (at least some) NAC-containing supplement products
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