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This localized depletion is strongly correlated with increased ventricular lactate, pointing to severe neuroinflammation, an overwhelmed central nervous system antioxidant network, and a direct physiological explanation for the profound cognitive dysfunction and "brain fog" experienced by patients

Gut microbiota and metabolic health among overweight and obese individuals

Mechanistically, oxidative stress activates p16-pRb effector pathway which is thought to play a vital role in SIPS mediation 11

Halin S, Hammarsten P, Adamo H, Wikstrom P, Bergh A

A lack of vitamin B12 doesnt directly lead to weight gain, however, so getting a B12 injection alone wont cause you to lose weight no matter how many times your doctor calls the injection a skinny shot