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In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]
Users who track their weight loss progress often find that resolving constipation with proper fiber supplementation reveals weight loss that was previously hidden by retained stool
Among the 4,076 participants, 80% were receiving ACE inhibitors, ARBs, or angiotensin receptor-neprilysin inhibitors, and 15.2% were on SGLT2 inhibitors
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This includes increasing insulin secretion, decreasing the secretion of glucagon, and reducing hunger
