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In addition, as semaglutide is not officially approved for chronic weight management, changes in facial appearance are not listed in the FDA label as adverse events [88]
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Clinicians should carefully consider individual patient characteristics, especially in those with preexisting gastrointestinal conditions, when selecting GLP-1RAs and adjusting dosages
Suckfull M, Althaus M, Ellers-Lenz B, et al
IGF-1 decreased miR-143 expression and increased IGF1R expression in PC-3 and DU145 cells, and made these cell lines more resistant to docetaxel treatment, suggesting that IGF-1 levels are also involved in resistance to treatment in PCa (54)
This means it stays in your body and exerts its action (to suppress appetite) for a longer time, which helps with weight loss
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