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To evaluate NRF2-dependent regulation of these genes, we generated two KEAP1 -mutant NSCLC cell lines (A549 and NCI-H460) stably integrated with a doxycycline (dox)-inducible shRNA targeting NRF2
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Because cancer cells have significantly elevated glutathione (GSH) levels and a highly reducing intracellular environment, GSH serves as an effective trigger for selective activation of nanocarriers
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