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(ii) Cu 2+ induces the secretion of acidic SMase from leukocytes which in turn leads to accumulation of erythrocytic ceramide [131] and (iii) treatment of erythrocytes with extracellular SMase resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization [125]

The key lies in finding the right balance between activity and recovery, ensuring that movement supports rather than compromises joint function

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Proteolytic Resistance: Protecting the peptide backbone from rapid enzymatic degradation by local endopeptidases

Biochim Biophys Acta 2000