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J., Treppendahl, M
While effective for weight loss, constipation is a recognized gastrointestinal adverse effect, affecting approximately 11-16% of patients depending on dose, according to the FDA prescribing information
Reduce dose or split into smaller, more frequent injections
prescribing information, revised in December 2025, integrates these indications for both injection and tablet formulations, while incorporating updated guidance on severe gastrointestinal events, acute kidney injury, and periprocedural aspiration risk
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