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The biological-product classification dispute must continue through the administrative or judicial process
These findings highlight a shift from a baseline inflammatory profile associated with ocular surface damage toward a post-treatment milieu in which cytokine expression parallels improvements in tear production and PROMs
Moreover, it appears that it is the membrane-bound form of the enzyme, on sites such as the luminal surface of capillary endothelial cells, which is more important for GLP-1 degradation than the circulating (soluble) enzyme (74, 75), questioning the relevance of any association between the plasma activity per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity
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(2013, Nature Medicine) found that L-carnitine is metabolized by intestinal microbiota to trimethylamine-N-oxide (TMAO), a proatherogenic substance associated with increased CVD risk
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